Long-term oxygen therapy had a damaging effect on rats with induced idiopathic pulmonary arterial hypertension (PAH), leading to poorer outcomes and reduced survival rates. That finding was reported in the study “Oxygen therapy may worsen the survival rate in rats with monocrotaline-induced pulmonary arterial hypertension,” and published in…
More than 700 medical experts, pharmaceutical executives, patient advocates, and others are expected to converge on Washington, D.C., next month for the 2018 NORD Rare Diseases & Orphan Products Breakthrough Summit. The Oct. 15-16 event, sponsored by the National Organization for Rare Diseases (NORD), takes place at the…
Off-label use of pulmonary arterial hypertension (PAH) medications to treat patients with pulmonary hypertension caused by left heart disease (PH-LHD) is common, despite a lack of supporting clinical data. Now, a systematic review and pooled analysis of several clinical…
Exhaled breath temperature could serve as a potential prognostic biomarker for patients with pulmonary hypertension (PH), a new study shows. The study, “Exhaled Nitric Oxide and Exhaled Breath Temperature as Potential Biomarkers in Patients with Pulmonary Hypertension,” was published in the journal Biomed Research International. There is a…
Idiopathic pulmonary arterial hypertension (IPAH) patients who failed to respond to treatment with Revatio (sildenafil), either alone or combined with other phosphodiesterase type 5 inhibitors, may benefit by switching to Adempas (riociguat), according to results of a pilot study. Adempas was also seen to ably help treatment-naive patients, using it as a first…
Actelion Pharmaceuticals’ Opsumit (macitentan) may be a potential therapy for portopulmonary hypertension, according to positive results from a Phase 4 clinical study. The data was presented at the European Respiratory Society (ERS) meeting, held Sept. 15-19 in Paris. The development of pulmonary arterial hypertension (PAH) in association with…
Stimulating the activity of an immune system receptor called TLR3 led to a reduction of pulmonary hypertension (PH) symptoms in a rat model of the disease, making TLR3 a promising therapeutic target for treating the condition in humans. Researchers said that using treatments to restore…
A study finds that, contrary to some reports, the use of inhaled nitric oxide can be effective in treating premature infants with acute pulmonary hypertension. The study, “The efficacy of inhaled nitric oxide treatment in premature infants with acute pulmonary hypertension,” was published in the journal Early Human…
A protein called RAGE was found to be an important contributor to the remodeling of blood vessels in pulmonary arterial hypertension (PAH). This is an important finding because it could lead researchers to develop new strategies that target RAGE protein as a potential treatment for the life-threatening disease. The RAGE protein,…
Pregnancy among women with heart diseases is generally safe, with just a few deaths being reported in the ROPAC registry during a 10-year period. However, pregnancy was found to be linked to an increased mortality risk among women with pulmonary arterial hypertension (PAH). The most recent results of this…
Use of antidepressants during pregnancy doubles the risk for persistent pulmonary hypertension in the newborn (PPHN), a systematic review of several studies suggests. Out of the antidepressants analyzed, researchers proposed sertraline (brand name Zoloft, marketed by…
PhaseBio Pharmaceuticals has secured $34 million in Series D financing to advance the clinical development of PB1046, an investigational therapy for pulmonary arterial hypertension (PAH), as well as its lead product candidate PB2452, the company announced in a press release. PB1046 is being developed as a once-weekly…
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