News

Testing for EIF2AK4 Mutations May Help Distinguish Between PAH and Other Severe PH Diseases, Study Says

Patients with mutations in the EIF2AK4 gene have worse outcomes than others with pulmonary arterial hypertension (PAH), researchers report, suggesting that genetic tests be given these people — often diagnosed with PAH — to determine if they actually have pulmonary vena-occlusive disease (PVOD) or pulmonary capillary hemangiomatosis (PCH) and can be treated…

How Advanced Lung Cancer Might Lead to PAH Traced in Study

Nearly one in every two people with advanced lung cancer also have pulmonary arterial hypertension, a study published in the journal Science Translational Medicine reports. The study, “Lung cancer–associated pulmonary hypertension: role of microenvironmental inflammation based on tumor cell-immune cell crosstalk,” showed that lung cancer progression leads…

CTEPH Patients Suffer Depression, Anxiety, Poorer Quality of Life Than Those with PAH, Study Finds

A retrospective study found that patients with chronic thromboembolic pulmonary hypertension (CTEPH) have more pronounced decreases in mental health than those with pulmonary arterial hypertension (PAH). The German study, “Anxiety, Depression, and Health-Related QOL in Patients Diagnosed with PAH or CTEPH,” appeared in the journal Lung. PAH and…

Preclinical Data Supports Sotatercept Being Tested in People with PAH, Acceleron Reports

Preclinical work supports the potential of  sotatercept to be a first-in-class disease-modifying therapy for pulmonary arterial hypertension (PAH) and to moving the investigational therapy into a Phase 2 trial in patients, Acceleron Pharma announced. Sotatercept is a  trap molecule for members of the transforming growth factor-beta (TGF-beta) superfamily. A growing body of evidence…

INOpulse as Potential PH Treatment Advancing in Studies, Bellerophon Says

Development work on INOpulse as a treatment for pulmonary hypertension is advancing in all three patient groups, Bellerophon Therapeutics announced when sharing its third quarter financial results. Bellerophon is developing INOpulse — inhaled nitric oxide delivered with the help of a portable device — for patients with pulmonary arterial hypertension…