News

A compound in a plant that is used in traditional Chinese medicine lowered the lung blood pressure of rats with pulmonary arterial hypertension, a study shows The compound, osthole, did this by decreasing levels of proteins associated with PAH, researchers said. The study, “Global Proteomics Deciphered Novel-Function of…

Plans for a Phase 2 clinical trial of levosimendan, a proposed treatment for pulmonary hypertension associated with heart failure and preserved ejection fraction, will soon be submitted to the U.S. Food and Drug Administration for approval, Tenax Therapeutics announced. In a pre-application meeting with company executives, the FDA supported the study’s proposed…

Credit: phaware Every year, World PH Day is celebrated on May 5. This year the virtual non-profit #phaware global association is inviting friends of the pulmonary hypertension (PH) community to become a #phaware brand ambassador and participate in activities worldwide to raise awareness of the…

Patients with higher exercise capacity present a reduced risk of pulmonary arterial hypertension-associated death or hospitalization, according to results of a Phase 3 clinical trial. The research was published in the journal PLOS One, in a study titled “Association between six-minute walk distance and long-term outcomes in patients…

The University of Virginia’s (UVA) Pulmonary Hypertension Center has been recognized as a Center of Comprehensive Care by the Pulmonary Hypertension Association (PHA). The PHA-accredited PH Care Centers initiative aims to establish an accreditation program for centers with special expertise in pulmonary hypertension (PH), particularly pulmonary arterial hypertension…

A protein called KLF15 has an important protective role in the lung, according to the findings of Johns Hopkins researchers. KLF15 was found to be a critical regulator of genes that are necessary for the maintenance of proper lung blood vessels’ function. In addition, the protein was shown to…

People with systemic sclerosis (SSc) that have borderline high pulmonary arterial pressure are at increased risk of developing pulmonary hypertension (PH), and may benefit from regular examinations through right heart catheterization, a study found. Pulmonary hypertension often appears as a disease complication of systemic…

Poor renal function is linked to an increased prevalence of pulmonary hypertension (PH) in patients with chronic kidney disease (CKD), a retrospective study suggests. The study, “Epidemiology and risk factors in CKD patients with pulmonary hypertension: a retrospective study,” was published in the journal BMC…

Bardoxolone methyl, Reata Pharmaceuticals’ treatment candidate for pulmonary hypertension (PH), improves exercise capacity and has a safe profile in patients with PH associated with interstitial lung disease (ILD), according to top-line results from a Phase 2 clinical trial. ILD is a group of several lung…

American researchers have identified three blood-flow measurements that could help doctors predict the outcomes of people whose pulmonary hypertension stems from a serious heart condition. The discovery applies to PH patients whose lung blood pressure disorder is associated with heart failure with preserved ejection fraction, or PH-HFpEF. A diagnosis of…

Deficiency of an enzyme called granzyme B leads to deposits of calcium in pulmonary blood vessels, contributing to the defects found in hypoxic pulmonary arterial hypertension (PAH), an animal study suggests. The study, “Granzyme B deficiency promotes osteoblastic differentiation and calcification of vascular smooth muscle cells in…

Genetic sequencing and the speed with which it can help diagnose a child’s disease — in addition to revealing the genes that cause at least half of the 7,000 rare diseases currently known — was the focus of a discussion by three top New York geneticists. The Feb. 28 conference,…