News

Tracleer Becomes First FDA-approved Therapy in U.S. for Children with Pulmonary Hypertension

Tracleer (bosentan) has become the first therapy to obtain U.S. regulatory approval for treating pulmonary hypertension in children. The Food and Drug Administration authorized it for children aged 3 and older who have idiopathic or congenital pulmonary arterial hypertension (PAH). Actelion Pharmaceuticals, the company that holds the marketing license for…

FDA Declines SteadyMed’s New Drug Application for Trevyent, Delivered via PatchPump, to Treat PAH

The U.S. Food and Drug Administration (FDA) has declined SteadyMed Therapeutics‘ new drug application (NDA) for its Trevyent (treprostinil injection) therapy to treat pulmonary arterial hypertension (PAH). SteadyMed, with offices in San Ramon, California, and in Israel, had submitted its NDA in July 2017. But the application was denied on Aug. 31…

Arena to Present New Information on Its Pulmonary Hypertension Therapy Ralinepag in Barcelona

Arena Pharmaceuticals will present new information in Barcelona this weekend on its pulmonary hypertension therapy ralinepag, which a clinical trial showed improved patients’ heart blood vessel resistance and exercise capacity. The two presentations at the European Society of Cardiology Congress, Aug. 26-30, will focus on the results of preclinical-trial studies in rats and…

VMS Heart Analysis System Accurately Evaluates Right Ventricle Remodeling in PH Patients, Study Shows

Ventripoint Diagnostics‘ VMS Heart Analysis System, which produces a two-dimensional (2D) volumetric reconstruction model of the heart, accurately measures small changes in the heart’s right ventricle volume and can be used in patients with pulmonary hypertension (PH), a new study finds. The study, “Two-dimensional knowledge-based volumetric reconstruction of the…

Estrogen Inhibitors Can Prevent and Treat PAH in Mice, Vanderbilt Study Finds

Estrogen inhibitors may treat pulmonary vascular disease by correcting metabolic defects in women with pulmonary arterial hypertension (PAH), say researchers at Nashville’s Vanderbilt University. Their study,“Oestrogen inhibition reverses pulmonary arterial hypertension and associated metabolic defects,” appeared in the European Respiratory Journal. Most people with hereditary PAH have mutations…

Lab Study Shows Positive Effects of Adcirca in Treatment of PAH

Adcirca (tadalafil) exerts a variety of positive effects that may explain why the therapy improves idiopathic pulmonary arterial hypertension (IPAH), according to an in vitro study. The study, “Tadalafil induces antiproliferation, apoptosis, and phosphodiesterase type 5 downregulation in idiopathic pulmonary arterial hypertension in vitro,” was published…