Abnormalities in blood levels of various microRNAs (miRNAs) — small RNA molecules that regulate other genes in protein production — may contribute to the development and progression of chronic thromboembolic pulmonary…
News
The Pulmonary Hypertension Association (PHA) is fundraising and advocating with a campaign called “Let Your Light Shine” this November for this year’s pulmonary hypertension (PH) awareness month. “The efforts of PHA and the PH community are making a tremendous impact on the lives of those affected by PH,”…
Adults with severe pulmonary arterial hypertension (PAH) awaiting lung transplants can safely participate in pulmonary rehabilitation and maintain or improve exercise capacity, a study found. Pulmonary rehabilitation led to modest improvements in measures of aerobic training and in muscle training volumes with no major adverse events. However, participation in…
Children with pulmonary hypertension (PH), characterized by high blood pressure in the lungs that can make exercising difficult, are more likely to be active if physical activity is fun, allows them to be with friends, and puts them in a safe place where they feel included, a study has…
Researchers at Monash University in Australia will use newly granted funding to advance their work on a project that aims to create a novel disease-modifying treatment for pulmonary arterial hypertension (PAH). That funding came from Biocurate, a venture led by the University of Melbourne and Monash that aims…
An upcoming clinical trial will test whether empagliflozin, a drug widely approved to treat diabetes and heart failure, might be able to improve heart health in people with pulmonary arterial hypertension (PAH). The trial will be led by scientists at Cleveland Clinic, with study sites planned at two…
Long-term oxygen improves exercise capacity in people with pulmonary arterial hypertension (PAH) or chronic thromboembolic pulmonary hypertension (CTEPH), a study suggests. Twelve weeks of supplemental oxygen led to a significant and clinically relevant improvements in exercise capacity, as assessed with the six-minute walking distance test (6MWD), by 42…
A new device to deliver inhaled nitric oxide gas to newborns with pulmonary hypertension (PH), is now available for use in hospital neonatal intensive care units (NICUs) across the U.S. The rollout follows recent approval from the U.S. Food and Drug Administration of the next-generation device, the INOmax…
Exosomes, a type of small vesicle released by mesenchymal stem cells (MSCs), helped reduce vascular remodeling and ease pulmonary hypertension (PH) symptoms in a rat model of the disease, a study found. Exosome effects were tied to a modulation of the NF-kB/BMP pathway involved in vascular remodeling, a set…
Most adults with pulmonary arterial hypertension (PAH) who switched to Uptravi (selexipag) from other medications in its class achieved stabilization or a lessening of disease severity, according to an analysis of real-world treatment data from the SPHERE registry. Clinical outcomes were also generally good for Uptravi-treated PAH patients…
Liquidia has expanded a license agreement with Pharmosa Biopharm, acquiring rights to market L606, a potential inhaled formulation of treprostinil now in a Phase 3 study, across Europe, Japan, and other regions as well as in North America. The two-part and open-label Phase 3 clinical…
The use of selenium supplements — an essential mineral naturally present in many foods and added to others — reduced blood vessel remodeling, a hallmark of pulmonary arterial hypertension (PAH), in the lung, according to a new study. Selinium has antioxidant properties and may help protect cells from damage.
