News

PDE5 Inhibitors Improve Blood Flow, Exercise Capacity in PH: Analysis

Treatment with phosphodiesterase-5 (PDE5) inhibitors can improve blood flow parameters and exercise capacity in people with pulmonary hypertension (PH), according to a new analysis of clinical trial data. “The study found that the reduction in mean PAP [peripheral arterial pressure] was significantly greater in patients receiving PDE5 inhibitors,” the…

CTEPH Underdiagnosed After Pulmonary Embolism: Study

The incidence of chronic thromboembolic pulmonary hypertension (CTEPH) after an episode of acute pulmonary embolism (PE) is likely underestimated, a study suggests. This occurs despite the high frequency of symptoms consistent with CTEPH, underscoring that an appropriate diagnostic work-up of CTEPH is rarely undertaken. The study, “CTEPH: a…

Gut Metabolite TMAO Linked to Worse Prognosis

People with pulmonary hypertension (PH) who had elevated blood levels of the trimethylamine N-oxide (TMAO) molecule were at a five times greater risk of a poor prognosis than patients who didn’t have high levels, according to a recent study. High levels of this gut-derived metabolite were generally linked to…

Two Likely Biomarkers for PAH Diagnosis, Progression Identified

Two new biomarkers to assess pulmonary arterial hypertension (PAH) were discovered through large-scale analysis of gene activity profiles using computer software, a study reported. These biomarkers, the activity of the genes PNISR and HNRNPH1, may help diagnose PAH, monitor its progression, or measure responses to therapy. They also may highlight…

PAH Patients May Lack Enough of Some Key Vitamins, Minerals

People with pulmonary arterial hypertension (PAH) may lack some key vitamins and minerals their bodies need daily to stay healthy, which may lessen their vitality, according to a small study from the Netherlands. Besides the known lack of vitamin D and iron, researchers observed lower than recommended levels of…

Top 10 Pulmonary Hypertension Stories of 2022

Over the past year, the team here at Pulmonary Hypertension News has brought you up-to-date coverage of the latest developments in research, care, and treatment related to pulmonary hypertension (PH). We hope to continue to be a resource for the PH community in the coming year. Here is a…

Unhealthy Behaviors, Thoughts Can Cause Depression or Anxiety

Unhealthy changes in cognition, like a focus on worries, can lead to anxiety in people with pulmonary hypertension(PH), while those in behavior, like social avoidance, may cause depression, according to a U.K. study. Greater dyspnea, or shortness of breath, was also a contributing factor when paired with these cognitive or…