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Zymedi is collaborating with the National Heart, Lung, and Blood Institute (NHLBI) to advance the development of its first-in-class pulmonary arterial hypertension (PAH) treatment candidate ZMA001. The South Korea-based company and the NHLBI, part of the National Institutes of Health, have signed a clinical Cooperative Research and Development…

Note: This story was corrected July 10, 2023, to reflect that attendees at the European Cardiac and Respiratory Societies discussed the therapy Tyvaso with regard to the 2022 pulmonary hypertension diagnosis and treatment guidelines. Pulmonary hypertension (PH) experts are calling for care protocols to expedite patient referrals to…

Algorithm Sciences, which is developing PulmoProst to treat pulmonary arterial hypertension (PAH), has acquired all assets of Flownix Medical, including the Prometra II pump that would deliver the potential therapy. PulmoProst is an infusion formulation of iloprost, a synthetic version of naturally occurring prostacyclin, a substance that…

Liquidia has licensed the rights in North America to L606, a novel inhaled formulation of treprostinil that’s being tested in trials of people with pulmonary arterial hypertension (PAH) or pulmonary hypertension associated with interstitial lung disease (PH-ILD). “L606 is the perfect life-cycle complement to our pipeline and…

Janssen Pharmaceuticals has submitted an application in Europe asking regulatory authorities to approve the company’s combination therapy of macitentan and tadalafil — developed as a single tablet — for pulmonary arterial hypertension (PAH). The filing comes less than a month after Janssen submitted a similar application seeking approval…

Pregnant women with mild pulmonary hypertension (PH) show a significantly lower risk of maternal and fetal complications than those with moderate-to-severe PH, according to a study from China. “For patients with mild pulmonary hypertension and good cardiac function, continued pregnancy or even delivery should be considered under multidisciplinary monitoring,”…

Liqrev, a new liquid formulation of sildenafil designed for patients who have trouble swallowing tablets, is now available in the U.S., according to an announcement from CMP Pharma, its developer. Liqrev was approved by the U.S. Food and Drug Administration earlier this year as a treatment to improve…

Long COVID syndrome can be common among people with pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH), affecting more than 60% of patients infected with the SARS-CoV-2 virus in a study from Poland. Despite the persistence of COVID-19 symptoms, no change was evident in the patients’ risk of…

Developing chronic thromboembolic pulmonary hypertension (CTEPH) within two years after a venous thromboembolism (VTE), which occurs when a blood clot forms in a vein, nearly doubles the risk of long-term death, according to a large study from Denmark. Researchers also observed that all types of pulmonary hypertension (PH)…

Treatment with intravenous Revatio (sildenafil) can improve oxygen delivery and heart health in some premature babies with pulmonary hypertension, although more than four in 10 patients don’t respond to it. “Our study adds new insights on preterm and [very low birth weight]-infants with sildenafil treatment for primary early PH…

Persistent exercise intolerance in pulmonary arterial hypertension (PAH) patients with treatment-related improvements in blood pressure was associated with impaired muscle function and strength, a study revealed. Because many of the study’s participants have lived with PAH for many years, muscle function may have been compromised, the researchers noted. Interventions…

Treatment with cannabidiol (CBD) for three weeks lowered signs of cardiac fibrosis, or scar tissue build-up, in a rat model of pulmonary hypertension (PH). The findings indicate that CBD may be beneficial for boosting heart function in PH patients via inhibition of certain pro-fibrotic signaling pathways, according to researchers,…