Treatment with nintedanib lowered lung blood pressure in a rat model of pulmonary arterial hypertension by preventing cells of blood vessel walls from changing identity, and by inhibiting smooth muscle cells from growing excessively, a study has found. The study, “Nintedanib ameliorates experimental pulmonary arterial hypertension via inhibition…
The heart rhythm of patients with pulmonary hypertension (PH) has limited ability to adjust to changes, compared to unaffected people used as controls in a new pilot study. The findings also revealed that assessing heart rhythm complexity (HRC) parameters may improve the ability to predict PH. The research, “…
Specific biomarkers are present in higher levels in the blood of people with pulmonary hypertension (PH), and could be used to aid in diagnosis, a study says. Titled “Analysis of Novel Cardiovascular Biomarkers in Patients With Pulmonary Hypertension (PH),” the study was published in the journal …
An anti-inflammatory diet with high amounts of protein, fish oil, the amino acid leucine, and oligosaccharides reduced changes in heart and skeletal muscle in a female mice model of pulmonary arterial hypertension (PAH), a study says. The findings of the study, “Anti-inflammatory nutrition with high protein attenuates…
Interleukin-17 (IL-17), a proinflammatory protein, appears to play important roles in the development of hypoxic pulmonary hypertension (HPH), a common and potentially life-threatening condition in people with chronic lung diseases, an early study suggests. Lung tissue of patients with HPH show increased IL-17 levels, and preventing its production or…
A tiny RNA molecule known as microRNA-410 (miR-410) was seen to slow the proliferation of endothelial cells in the lung and ease pulmonary vascular remodeling in a mouse model of pulmonary arterial hypertension (PAH). These findings suggest that raising miR-410 levels in the lung may offer a way of…
A new international consortium based in Paris, and funded largely by the 28-member European Union, intends to speed the diagnosis of rare diseases, while also accelerating the development of treatments for the 95% of such illnesses that currently don’t have one. The European Joint Programme on Rare Diseases (EJP…
Long-term use of Orenitram led to moderate but durable, and dose dependent, improvements in exercise capacity in pulmonary arterial hypertension (PAH) patients, results from an open-label extension trial show. These findings were reported in the study “Long term study of oral treprostinil to treat pulmonary arterial hypertension:…
Increasing levels of the receptor Nur77 in cells lining the blood vessels of patients with pulmonary hypertension (PH) may help halt progression of the disease by enhancing the signaling of the BMPR2 gene, often mutated in PH, a study suggests. The study, “6-mercaptopurine, an agonist of Nur77, reduces…
Left heart dysfunction may play an important role in severe pulmonary arterial hypertension (PAH), and should be monitored to optimize treatment, according to new research. The study, “Impact of Severe Pulmonary Arterial Hypertension on the Left Heart and Prognostic Implications,” was published in the Journal…
Extracorporeal life support improves the lung performance of people with idiopathic pulmonary arterial hypertension (iPAH) who need a lung transplant. But patients usually enter the transplant list at advanced stages of the disease, which leads to poor post-transplant outcomes. A study with that finding, “The role of…
Abbott’s CardioMEMS HF system — a wireless heart failure monitor — can be safely used to monitor blood flow (hemodynamics) changes and help predict the risk of heart failure in people with pulmonary arterial hypertension (PAH), results from a pilot trial show. Additional studies in larger…
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