Higher levels of certain high-density lipoproteins (HDLs) improve the survival of pulmonary arterial hypertension (PAH) patients, according to a recent evaluation of two PAH patient cohorts. Targeting certain HDL subclasses may improve future PAH treatment. The study, “Reduced plasma levels of small HDL particles transporting fibrinolytic proteins in pulmonary…
Analytics 4 Life and Actelion Pharmaceuticals have announced a collaboration agreement to test CorVista as a potential cardiac imaging technology for the diagnosis of pulmonary hypertension (PH). CorVista is a non-invasive diagnostic application that uses Phase Space Tomography to measure cardiac patterns, and to discover irregularities…
Genetic variants close to the SOX17 and the HLA-DPB1 genes are linked to pulmonary arterial hypertension (PAH), according to the findings of the largest genetic study to date in PAH patients. The study, “Genetic determinants of risk in pulmonary arterial hypertension: international genome-wide association studies and meta-analysis,” was published in the…
Low diffusing capacity of the lung for carbon monoxide (DLCO) is a key indicator of mortality in group 3 pulmonary hypertension (PH), according to a study. The finding suggests a potential tool to asses patient risk based on DLCO outcomes. The study, “Survival in pulmonary hypertension due to chronic…
Switching treatment from United Therapeutics’ Tyvaso (inhaled treprostinil) to Actelion’s Uptravi (oral selexipag) is safe and considered convenient by patients with…
The U.S. Food and Drug Administration (FDA) granted Breakthrough Device Designation to software being developed by Bayer and Merck — known as MSD outside the U.S. and Canada — to help identify chronic thromboembolic pulmonary hypertension (CTEPH). CTEPH is a rare form of pulmonary hypertension thought to…
Uptravi (selexipag) is now available with public funding for pulmonary arterial hypertension (PAH) patients in Canada living in nine of the country’s 1o provinces, patient groups announced. The governments of British Columbia and Nova Scotia recently added Uptravi to their publicly funded medicines — likely making Actelion’s PAH…
Biotechnology company Morphogen-IX recently announced that it will be further developing MGX292 as its treatment candidate for pulmonary arterial hypertension (PAH). The company’s decision is supported by previous preclinical studies that have shown the potential of MGX292, a signaling protein analogue, as a safe and effective therapy for PAH.
PhaseBio Pharmaceuticals started dosing its investigational compound PB1046 in patients with pulmonary arterial hypertension (PAH) in a Phase 2b clinical trial. The first patient to receive the therapy was dosed by Murali Chakinala, MD, professor of medicine at the Washington University School of Medicine (WUSM), and director of…
A subset of bone marrow cells known as proangiogenic cells (PACs) may drive the development of pulmonary arterial hypertension (PAH), according to a study that also showed that blocking a specific serotonin receptor may be a therapeutic strategy for the disease. The study, “Bone Marrow-Derived Proangiogenic…
The Stanford University School of Medicine is the first clinical site for a Phase 2 trial testing levosimendan as a potential treatment for pulmonary hypertension associated with heart failure and preserved ejection fraction (PH-HFpEF), Tenax Therapeutics recently announced. Ejection fraction is the amount of blood that the…
A receptor protein present in immune cells is a potential target for treating pulmonary hypertension (PH), according to a new study. The findings — based on patient lung tissue and animal experiments – showed a link between low levels of Toll-like receptor 3 (TLR3) and the disease. Published in the…
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