Gemcitabine, chemotherapy for solid tumors, may lead to PAH

Gemcitabine, a chemotherapy given to treat solid cancers, may drive the onset of pulmonary arterial hypertension (PAH) in patients or worsen existing PAH, a recent study reports. Stopping treatment with gemcitabine, with or without a subsequent PAH-approved treatment, led to clinical improvement or disease stabilization for a majority…

Treatments That Target and Kill Only Diseased Cells in PAH Possible, Researchers Say

Medications that specifically trigger cell death in remodeled blood vessels, without damaging the heart or healthy blood vessels, may be used to treat pulmonary arterial hypertension (PAH), researchers suggest. Their study, “Apoptosis-based therapy to treat pulmonary arterial hypertension,” published in the Journal of Rare Diseases Research & Treatment,…