Pharmacologically inhibiting an enzyme called tryptophan hydroxylase 1 (TPH1) that plays a role in serotonin biosynthesis can significantly reduce pulmonary arterial pressure, as well as pulmonary blood vessel wall thickness and blockade, according to a study published in the Journal of Pharmacology and Experimental Therapeutics.
Karos Pharmaceuticals, a start-up focused on the selective modulation of peripheral serotonin synthesis, recently reported positive results from its Phase 1 clinical trials evaluating KAR5585, a compound being developed to treat orphan diseases such as pulmonary arterial hypertension (PAH) and carcinoid syndrome. KAR5585 is a first-in-class, selective inhibitor of tryptophan hydroxylase…
Karos Pharmaceuticals announced that is advancing its small molecule drug candidate, KAR5585, in clinical testing as a treatment for pulmonary arterial hypertension (PAH) and other rare diseases characterized by fibrosis. A number of agents have recently been introduced as therapeutic drugs for PAH. Among them, KAR5585 is a first-in-class, selective inhibitor of an enzyme…
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