Some PAH Patients May Benefit from Switch to Adempas

Intermediate-risk pulmonary arterial hypertension (PAH) patients may see their symptoms improve after switching from phosphodiesterase-5 inhibitors (PDE-5i) to Adempas (riociguat), results from the Phase 4 REPLACE clinical trial show. The transition to Adempas also appears to be a safer option than with PDE-5i maintenance therapy. The study, “Switching…

Switching to Adempas Improves Clinical Outcomes in Intermediate-risk PAH Patients, Phase 4 Trial Shows

People with intermediate-risk pulmonary arterial hypertension (PAH) who failed to respond adequately to phosphodiesterase-5 inhibitors (PDE5i) show significant benefits when transitioned to Adempas (riociguat) treatment, a Phase 4 trial has found. A total of 41% of patients who made that transition experienced significant clinical improvements, compared with…

Adempas May Benefit PAH Patients Who Fail to Respond to PDE5 Inhibitors, Trial Indicates

Bayer’s Adempas (riociguat) can improve the lung and heart functioning of pulmonary hypertension patients who fail to respond to phosphodiesterase-5 inhibitors (PDE5i), a Phase 3 clinical trial suggests. The RESPITE trial also showed that Adempas can improve biomarkers of pulmonary arterial hypertension, or PAH. Researchers published the study in the European…