Approved Treatments for Pulmonary Hypertension

Adcirca (tadalafil) is used to ease symptoms of pulmonary arterial hypertension (PAH). It is designed to relax the smooth muscles of the arteries, leading to widening of the arteries and a reduction of blood pressure. This improves the transport of oxygen around the body, which can improve a patient’s ability to exercise.

Adempas (riociguat) was developed for chronic thromboembolic pulmonary hypertension (CTEPH) and PAH. It is designed to relax arterial muscle walls, which causes the arteries to widen, allowing blood to flow more freely. The result is lower blood pressure and increased oxygen flow around the body.

Flolan (epoprostenol GM) can be prescribed to PAH patients to improve exercise capacity and circulation, and ease symptoms. It is a synthetic variant of prostacyclin, a member of a group of molecules called prostaglandins, which naturally exist in the body and are involved in many biological functions, including dilating and relaxing blood vessels.

Letairis (ambrisentan) is approved to treat the symptoms of PAH both as a monotherapy and in combination with Adcirca in the U.S. and Europe. It is an endothelin type-A receptor antagonist that relaxes the muscles and helps widen the arteries, lowering blood pressure and allowing for oxygen to be transported more effectively around the body.

Opsumit (macitentan) is an oral therapy approved to reduce the risk of disease progression and hospitalization in adults with pulmonary arterial hypertension. It’s available as oral tablets to be taken once daily, with or without food.

Opsynvi (macitentan and tadalafil) is an oral therapy approved in the U.S. for treating adults with PAH in World Health Organization functional class 2 or 3. It’s designed to reduce the risk of clinical worsening and hospitalizations, while improving exercise capacity in patients. Opsynvi is the first single-tablet combination treatment available to PAH patients in the U.S.

Orenitram is an extended-release oral formulation of treprostinil used to  improve exercise ability and delay clinical worsening in PAH patients. It is a synthetic form of prostacyclin, which helps with the effective dilation of the arteries in the lungs and other parts of the body and inhibits blood cells called platelets from clumping and blocking arteries.

Remodulin (treprostinil) is a therapy used to treat PAH symptoms. It is administered as a continuous infusion or as an injection under the skin or into a vein. It is a man-made form of  prostacyclin, which helps blood vessels relax and widen. Prostacyclin also prevents platelet activation and aggregation.

Revatio (sildenafil) is used to slow the progression of PAH and improve the ability to exercise. Revatio is a phosphodiesterase-5 (PDE-5) inhibitor that helps with vasodilation, leading to a reduction in blood pressure. This increases circulation through the lungs, which helps transport oxygen around the body and reduces the burden on the heart.

Tracleer (bosentan) is an oral medication approved to improve exercise ability and reduce clinical worsening in adults and certain children with pulmonary arterial hypertension. It’s available as oral tablets or suspension to be taken twice daily, with or without food.

Tyvaso is an inhaled formulation of treprostinil administered via a hand-held, portable device. It is prescribed to ease PAH symptoms. In 2021, it became the first therapy approved in the U.S. for the treatment of PH associated with interstitial lung disease. Interstitial lung diseases are a large group of disorders characterized by fibrosis, or scarring, in the lungs.

Uptravi (selexipag) is an approved therapy used to delay disease progression and reduce the risk of hospitalization in people with pulmonary arterial hypertension. It’s available in both oral and intravenous (into-the-vein) formulations.

Veletri (epoprostenol) is an infusion therapy approved to improve exercise capacity in people with pulmonary arterial hypertension. It’s administered via a continuous intravenous (into-the-vein) infusion.

Winrevair (sotatercept-csrk) is an injection therapy approved in the U.S. for adults with PAH. It is designed to improve exercise capacity and World Health Organization (WHO) functional class, and to reduce the risk of disease-related clinical problems. The therapy is administered via subcutaneous, or under-the-skin, injections.

Yutrepia (treprostinil) is an inhaled therapy approved in the U.S. to improve exercise capacity in people with PAH and PH-ILD. The treatment is a dry powder formulation of treprostinil.