A study published in the journal Respiratory Medicine Case Reports revealed a case where a patient with idiopathic pulmonary fibrosis (IPF) was successfully treated for severe pulmonary hypertension (PH) with bosentan. The study is entitled “Bosentan for…
Despite improved understanding of the etiology of pulmonary arterial hypertension (PAH), the condition remains a severe and progressive disease, ultimately leading to right-sided cardiac failure. It continues to register significant morbidity and early mortality, with estimates showing that 1,000 Americans are diagnosed with PAH per year. Research and clinical advancements over…
A recent systematic review conducted by a research team from the University of Toronto in Canada sought to present the current state of agreement regarding the appropriate physical examination necessary for diagnosis of pulmonary hypertension (PH). The review, entitled “Utility of the Physical Examination in Detecting Pulmonary…
The Pulmonary Hypertension Association (PHA) has just announced a fresh set of accredited Pulmonary Hypertension Care Centers (PHCC) as part of a program aimed towards enhancing the nation’s overall quality of healthcare and pulmonary hypertension patient outcomes. These eleven newly-accredited PHCCs have brought the total number of PHA-accredited centers…
According to a study conducted by a team of researchers at the Department of Anesthesia, Hospital for Sick Children, in Toronto, Canada, children with pulmonary hypertension are at high risk of serious complications and even death associated with anesthesia and surgery. The study titled “The Impact of…
A team of Researchers led by Antje Prasse from the Department of Pneumology, University Medical Centre in Freiburg, Germany identified that macrophage activation and other cellular events may be part of the cause of acute exacerbations in idiopathic pulmonary fibrosis. Idiopathic pulmonary fibrosis (IPF) is a disease associated with high…
A team of researchers from Australia recently published a study, entitled “A comparison of the predictive accuracy of three screening models for pulmonary arterial hypertension in systemic sclerosis,” in the journal Arthritis Research & Therapy. Systemic sclerosis (SSc) is a multisystem connective tissue condition that causes…
A team of researchers from Taiwan sought to understand if, by suppressing a gene called TRPC, they could prevent hypoxia-induced pulmonary hypertension (PAH) in a murine model of PAH. The study entitled “Reducing TRPC1 Expression through Liposome-Mediated siRNA Delivery Markedly Attenuates Hypoxia-Induced Pulmonary Arterial Hypertension in a Murine…
Ascendis Pharma A/S is beginning its phase 1 single ascending dose study on healthy participants to evaluate a potential treatment for pulmonary arterial hypertension (PAH) called TransCon Treprostinil, as announced in a press release. The investigational therapy is one of a few promising drug candidates in the clinical stage biotechnology company’s portfolio, all…
San Diego, California-based biopharmaceutical company Arena Pharmaceuticals, Inc. just announced they have begun dosing patients in a Phase II clinical program for ralinepag, an orally available, non-prostanoid prostacyclin (IP) receptor agonist, formulated for the treatment of pulmonary arterial hypertension (PAH). Ralinepag has performed favorably in previous preclinical and clinical…
Misshapen and bloated mitochondria in the lungs may be the reason why so many elderly develop idiopathic pulmonary fibrosis (IPF), according to a study conducted at the University of Pittsburgh School of Medicine. The research, which will be featured on the cover of the February issue of the…
The Pulmonary Hypertension Association (PHA), the country’s leading non-profit organization for pulmonary hypertension (PH), maintains a daily blog on its website called PH Daily Beat, which provides those with PH helpful tips for living with the disease. Recently, the PHA put together…
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