News

Chiesi, Gossamer to advance seralutinib for PAH, other disorders

Chiesi Group has reached an agreement with Gossamer Bio to develop and market seralutinib for certain types of pulmonary hypertension (PH). The agreement seeks to support the therapy’s ongoing testing in pulmonary arterial hypertension (PAH) and to accelerate its development for pulmonary hypertension associated with…

Diet changes may treat pulmonary hypertension, study suggests

A diet poor in two amino acids called glutamine and serine may improve the health of pulmonary blood vessels and reduce the progression of pulmonary hypertension (PH), according to a recent study. Specifically, researchers found that these amino acids are used by cells in blood vessels to produce other…

PM20D1 levels may predict mortality risk in idiopathic PAH

Low levels of PM20D1, a molecule involved in metabolizing lipids, were identified as a risk factor for mortality in people with pulmonary arterial hypertension (PAH), a study reports. As a result, PM20D1, or peptidase M20 domain containing 1, may be a biomarker of disease prognosis, according to scientists. Lipid…

Two genes identified as potential drivers of PAH with HIV infection

Two genes were identified as potential drivers of pulmonary arterial hypertension (PAH) in people with HIV-1 infection in a bioinformatics study, offering new perspectives to uncover the underlying molecular mechanisms that link HIV infection and PAH. The genes ISG15 and IFI27 are established hub genes involved in the type…

Aiming to educate on all things PH for global Awareness Day May 5

More than 80 organizations globally, including the U.S.-based Pulmonary Hypertension Association (PHA), will unite on May 5 for World Pulmonary Hypertension Day, celebrated annually to heighten awareness of pulmonary hypertension (PH), which affects an estimated 75 million people worldwide. This year’s global initiative is led by PHA Europe,…

MACC1 seen as biomarker for PAH in bioinformatics study

MACC1, a gene that’s been linked to overgrowth of cancer cells, is more active in the lungs of people with pulmonary arterial hypertension (PAH) than in healthy individuals, a study out of China found, suggesting it could be used as a diagnostic biomarker for the disease. Researchers also observed…

Low circALMS1 levels could be prognostic biomarker in PH: Study

Low levels of circular RNA Alstrom syndrome protein 1, or circALMS1, may be associated with poor outcomes with pulmonary hypertension (PH), a study suggests. This may be because low circALMS1 levels promote higher numbers and the migration of pulmonary microvascular endothelial cells (PMECs), and reduce the cells’ death. PMECs…

Opsumit shows real-world safety, efficacy for CTD-PAH patients

Most people with pulmonary arterial hypertension (PAH) due to connective tissue disease (CTD) who are using Opsumit (macitenan) do so as part of a combination therapy, according to real-world evidence from two U.S. drug registry studies. Its safety and effectiveness, in terms of clinical outcomes, for these patients…


A Conversation With Rare Disease Advocates