Early diagnosis of pulmonary arterial hypertension (PAH), less than six months after symptom onset, improves five-year survival by 42% compared with delayed diagnosis of about two years or more, a recent study shows. The study also found that high blood pressure during heart contraction or normal pressure during heart relaxation,…
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Routine heart ultrasound measurements of left ventricular (LV) underfilling may significantly improve the prediction of poorer outcomes in people with pulmonary arterial hypertension (PAH) beyond currently used prognostic tools, a study has found. LV underfilling refers to the extent to which the left ventricle, the heart chamber that pumps…
Pulmonary hypertension (PH) in extremely premature infants — those born before 28 weeks of pregnancy — who also have bronchopulmonary dysplasia (BPD) usually resolves within the first year and does not…
Researchers have pinpointed Jagged-2, a signaling protein, as a potential therapeutic target for slowing or halting the progression of pulmonary arterial hypertension (PAH), based on a rat study. Suppressing Jagged-2 in a rat model reversed various processes that drive PAH progression, including inflammation and oxidative stress, a form of…
Two Phase 3 clinical trials are now recruiting participants to test Tenax Therapeutics‘ experimental therapy TNX-103 (oral levosimendan) in people with pulmonary hypertension associated with heart failure with preserved ejection fraction (PH-HFpEF). Tenax said its ongoing Phase 3 trial, LEVEL (NCT05983250), is expected to finish enrollment next year.
Uptravi (selexipag) may reduce blood pressure in the lungs of children with pulmonary arterial hypertension (PAH) and help them perform physical tasks, according to a meta-analysis. However, more long-term studies are still needed to confirm these benefits. The study, “Efficacy and Tolerability of Selexipag in…
A committee of the European Medicines Agency (EMA) has recommended expanding the indication for Winrevair (sotatercept-csrk), Merck’s approved injection therapy for adults with pulmonary arterial hypertension (PAH). Winrevair was approved in the European Union last year. It is currently indicated for use in combination with…
Having more severe bronchopulmonary dysplasia (BPD) — a chronic lung disease that occurs when a baby’s lungs aren’t fully developed — does not predict worse pulmonary hypertension (PH) in infants born preterm, according to a new study that used data from a patient registry. The researchers found that BPD is…
The U.S. Food and Drug Administration (FDA) has cleared Cereno Scientific’s request to launch a global Phase 2b trial of CS1, an oral therapy for people with pulmonary arterial hypertension (PAH). The company expects to begin enrolling patients in the second quarter of 2026, with top-line data anticipated…
People with chronic thromboembolic pulmonary hypertension (CTEPH) who have a high pulmonary arterial wedge pressure (PAWP) — a measure of pressure in the heart’s left atrium, which receives blood from the lungs…
Altered activity of a protein called PUM1 plays a key role in the development of pulmonary hypertension (PH), according to a new study done in animal and cell models. “Our study establishes PUM1 as a critical driver of PH pathogenesis [disease development],” the scientists wrote, adding that “this discovery…
Tiakis Biotech is set to advance its experimental therapy tiprelestat into a Phase 2 clinical trial for pulmonary arterial hypertension (PAH), after successfully finalizing the data package required for regulatory review. The planned study, dubbed ATHENA, will be led by Stanford University and will enroll about 90 patients…
