News

Three-molecule panel may help detect PAH in children with CHD

Measuring blood levels of three molecules — SAM, guanine, and NT-proBNP — could help identify pulmonary arterial hypertension (PAH) in children with congenital heart diseases (CHD), a study suggests. “This 3-marker panel has the potential to be used in clinical practice for the early diagnosis and screening of PAH-CHD,”…

PAH patients with or without CTD benefit similarly from Uptravi

Oral Uptravi (selexipag) provided similar clinical benefits for adults with connective tissue disease (CTD) associated with pulmonary arterial hypertension (PAH) as for those without CTD, according to a health claims database analysis. PAH patients with CTDs treated with Uptravi in real-world settings had similar risks of disease progression…

Self-compassion linked with anxiety, depression in PH: Study

Self-compassion, the act of being kind to oneself, was a significant predictor of anxiety and depression in adults with pulmonary hypertension (PH), a questionnaire-based study reported. Self-compassion also predicted the burden of those who care for patients. The findings suggest psychological and supportive interventions that build self-compassion are needed…

Long noncoding RNA may be new biomarker for PAH: Study

A long noncoding RNA molecule (lncRNA) — a long segment of RNA that regulates protein production in the body — may activate or inhibit genes associated with pulmonary arterial hypertension (PAH), according to researchers in China. In their study, a lncRNA was found at higher levels in children with…

Genes may be targets to treat right heart failure linked to PAH

Certain genes are differentially expressed, meaning they have different activity, in people with pulmonary arterial hypertension (PAH) whose right side of the heart fails to work as it should, a study found. Researchers believe that those genes, generally involved in regulating the electrical properties of the heart’s muscle cells,…

Left heart dysfunction poses great risk for CTEPH patients: Large study

Researchers have identified a significant risk factor that affects the prognosis of people with chronic thromboembolic pulmonary hypertension (CTEPH) in a large 26-year study. They found that elevated left ventricular filling pressure (LVFP), a measure of left heart function, was common in patients and predicted worse outcomes. Pulmonary hypertension…