A 68-year-old man with severe pulmonary arterial hypertension, or PAH — high blood pressure in the lungs — and multiple coexisting conditions saw considerable improvements after being given combination therapy with four different medications, a case study from the U.S. reports. Gains were seen in blood flow measures, the…
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Treatment with a combination of sildenafil and statins improved exercise capacity and reduced pulmonary arterial pressure in people with pulmonary hypertension (PH) secondary to chronic obstructive pulmonary disease (COPD) — a condition known for short as COPD-PH — according to a review study by scientists in China. These findings,…
Yutrepia (inhaled treprostinil), an inhaled dry powder formulation of treprostinil for pulmonary arterial hypertension (PAH) and pulmonary hypertension (PH) associated with interstitial lung disease (PH-ILD), has been prescribed to more than 900 people with PAH and PH-ILD since its approval in the U.S. in May, according to…
A study found that changes in immune cell metabolism may underlie increases in inflammatory signaling molecules in people with pulmonary arterial hypertension (PAH), suggesting that targeting immune cell metabolism could be a treatment strategy for the condition. The study, “Metabolic changes of peripheral blood mononuclear cells…
Tectonic Therapeutic plans to launch a Phase 2 clinical trial to test the impact of its therapy candidate TX45 on blood flow, or hemodynamics, in people with pulmonary hypertension and interstitial lung disease (PH-ILD). The move comes on the heels of positive results from part A of a…
People with portopulmonary hypertension (PoPH), a form of pulmonary arterial hypertension (PAH) usually associated with liver disease, show lower five-year survival rates than people with other types of PAH. Common markers that help predict outcomes in other PAH forms failed to identify high-risk patients in this group, however. But…
A 5-year-old boy with a neuroblastoma developed pulmonary arterial hypertension (PAH) after receiving high-dose busulfan to prepare for a stem cell transplant, but diagnosing his condition early and treating it with three lung pressure-lowering medications led to a full recovery. This treatment approach has significantly increased survival in children…
The degree of tricuspid regurgitation (TR), a cardiac abnormality detected in a heart ultrasound, may help predict the outcomes in people with pulmonary arterial hypertension (PAH), a study suggests. Those with more advanced TR were at a higher risk of death. This relationship was seen specifically in the subgroup…
Having pulmonary hypertension (PH) increases the risk of death, both in the short and long term, for individuals undergoing surgery for the heart valve disease aortic stenosis, a new analysis of published studies has found. Noting the older age, generally, of people with aortic stenosis undergoing the procedure, the…
Researchers identified two genes — PRDX1 and TNFAIP3 — whose activity levels could serve as diagnostic biomarkers for idiopathic pulmonary arterial hypertension (PAH). The genes are related to ferroptosis, an iron-dependent type of cell death involved in lung diseases and previously associated with PAH. “Our comprehensive analysis…
Exosomes — very small, sac-like structures — derived from stem cells may offer a potential treatment for hypoxic pulmonary hypertension (HPH) by preventing the abnormal growth and movement of muscle cells lining blood vessels. That’s according to data from a new study, conducted by researchers in China using lab-grown…
Among U.S. healthcare providers who treat pulmonary arterial hypertension (PAH), a patient’s current treatment, PAH cause, and coexisting health issues are the factors that most influence their willingness to prescribe first-line combination therapy over monotherapy, according to a new study. Most clinicians said they felt a single tablet combination…
