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An orally available small molecule, BI113823, successfully reversed the progression of severe, advanced pulmonary arterial hypertension (PAH) in a rat model, a study demonstrated. The experimental medicine lowered pulmonary blood pressure, reduced blood vessel thickening, suppressed inflammatory responses, and prevented right heart failure and death. These findings support the…

Elevated levels of three blood proteins — AMBP, LPL and glyoxalase I — may help identify and distinguish people with pulmonary hypertension linked to heart failure with preserved ejection fraction, called HFpEF-PH, from those with pulmonary arterial hypertension or PAH, a study suggests. Differentiating between the two is key,…

The blood levels of two molecules involved in vascular remodeling, a hallmark feature of pulmonary arterial hypertension (PAH), may be used as noninvasive predictive biomarkers of the disease, a small study suggests. The study, “Fibrinolytic markers could be useful predictors of severity in patients with pulmonary…

Adults with pulmonary arterial hypertension (PAH) or chronic thromboembolic pulmonary hypertension (CTEPH) who have trouble breathing at rest or with light activity may benefit from a procedure called respiratory rate modulation, a pilot, single-center study shows. The three-month procedure also led to lower symptom severity and decreased respiratory…

OxiWear has raised $1.25 million in funding to support the final steps in the commercialization of its ear-wearable device, designed to continuously monitor blood oxygen levels in people with pulmonary hypertension (PH). The funding round, initially with a target of $750,000, was well “oversubscribed,” the company reported in…

Bilateral lung transplant rapidly and effectively normalizes right ventricular function of the heart in children with severe pulmonary arterial hypertension (PAH) and heart failure, a study reports. These benefits in the 15 children evaluated were also independent of a child’s age, weight, and right ventricular (RV) impairment before the transplant. Given…

Treatment with the experimental medication KER-012 helped to prevent heart damage in a mouse model of pulmonary hypertension, new research shows. The findings were showcased by KER-012’s developer, Keros Therapeutics, at the American Heart Association (AHA) 2021 Scientific Sessions, held Nov. 13–15, according to a company press…

Low birth weight has been linked to an increased risk of pulmonary hypertension (PH) in premature infants needing oxygen therapy for at least 28 days, an analysis revealed. Additionally, the failure, after birth, of the blood vessels of the heart to close — before birth, they’re normally open to…

A large proportion of Swedish children younger than 7 who were diagnosed with pulmonary hypertension (PH) started treatment with vasodilators before age 1, and almost all of those treated received Revatio (sildenafil) as a first therapy, according to an analysis of a nationwide prescription registry. Despite treatment, mortality…

The U.S. Food and Drug Administration (FDA) has granted tentative approval to Yutrepia (treprostinil), previously known as LIQ861, as an inhalation treatment for pulmonary arterial hypertension (PAH), its developer Liquidia announced. Tentative approval means that Yutrepia has met all regulatory standards regarding quality, safety, and efficacy required for approval in the U.S. Because…

Local anesthesia is better than general anesthesia for both the mother and her baby when delivery is by cesarean section (C-section) and the woman has pulmonary arterial hypertension (PAH), a study suggests. These findings might help to guide doctors in selecting the best approach to anesthesia for women in labor.

Circulating endostatin, a protein that inhibits new blood vessel formation, appears to correlate well with mortality and disease severity in people with pulmonary arterial hypertension (PAH) in a large, observational study. Blood levels of endostatin show a “clear potential … as a robust prognostic biomarker in PAH” and could…