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At diagnosis, Black PAH patients have more severe disease: Study

At diagnosis, Black people with pulmonary arterial hypertension (PAH) tend to have more severe disease than their non-Black counterparts, a new U.S. study shows. The study, done using data from the University of Illinois Health Pulmonary Hypertension Clinic, further indicated that Black people being evaluated for PAH also tend…

Using 4-drug combination therapy adds up to healing in PAH

A 68-year-old man with severe pulmonary arterial hypertension, or PAH — high blood pressure in the lungs — and multiple coexisting conditions saw considerable improvements after being given combination therapy with four different medications, a case study from the U.S. reports. Gains were seen in blood flow measures, the…

Sildenafil-statin combo found to boost exercise capacity in COPD-PH

Treatment with a combination of sildenafil and statins improved exercise capacity and reduced pulmonary arterial pressure in people with pulmonary hypertension (PH) secondary to chronic obstructive pulmonary disease (COPD) — a condition known for short as COPD-PH — according to a review study by scientists in China. These findings,…

Yutrepia beefs up exercise capacity in adults with PH-ILD in trial

Yutrepia (inhaled treprostinil), an inhaled dry powder formulation of treprostinil for pulmonary arterial hypertension (PAH) and pulmonary hypertension (PH) associated with interstitial lung disease (PH-ILD), has been prescribed to more than 900 people with PAH and PH-ILD since its approval in the U.S. in May, according to…

Immune cell metabolism may point to PAH treatment strategy

A study found that changes in immune cell metabolism may underlie increases in inflammatory signaling molecules in people with pulmonary arterial hypertension (PAH), suggesting that targeting immune cell metabolism could be a treatment strategy for the condition. The study, “Metabolic changes of peripheral blood mononuclear cells…

PAH therapies extend survival in portopulmonary hypertension

People with portopulmonary hypertension (PoPH), a form of pulmonary arterial hypertension (PAH) usually associated with liver disease, show lower five-year survival rates than people with other types of PAH. Common markers that help predict outcomes in other PAH forms failed to identify high-risk patients in this group, however. But…

Early treatment aids in recovery of boy with chemotherapy-linked PAH

A 5-year-old boy with a neuroblastoma developed pulmonary arterial hypertension (PAH) after receiving high-dose busulfan to prepare for a stem cell transplant, but diagnosing his condition early and treating it with three lung pressure-lowering medications led to a full recovery. This treatment approach has significantly increased survival in children…

Study finds possible diagnostic biomarkers for idiopathic PAH

Researchers identified two genes — PRDX1 and TNFAIP3 — whose activity levels could serve as diagnostic biomarkers for idiopathic pulmonary arterial hypertension (PAH). The genes are related to ferroptosis, an iron-dependent type of cell death involved in lung diseases and previously associated with PAH. “Our comprehensive analysis…