When Gilead Sciences, Inc. initiated a clinical trial for first-line combination therapy for pulmonary arterial hypertension treatment, the company felt that their ambitious approach to developing a new, viable therapy for the disease was worthy of the clinical trial name “AMBITION.” Now, according to a…
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Photo Caption: “The Process is the product” – Pluristem’s 3D expansion technology allows for the production of different PLX cell products. Photo credit: Pluristem Therapeutics Inc. Haifa, Israel based Pluristem Therapeutics Inc. a drug developer specializing in placenta-based cell therapy products, has announced that licensee partner United Therapeutics…
Pulmonary hypertension occurs when there is an abnormal buildup of blood pressure pumped from the heart to the pulmonary vasculature, eventually causing the vessels in the lungs to constrict and lead to a reduction in blood oxygenation. At present, this deadly disease remains incurable, with a 68 percent chance…
Pulmonary hypertension is a condition caused by increased pressure in the pulmonary arteries. In advanced cases, its symptoms (shortness of breath, tiredness, chest pain) worsen and may limit all physical activity. Now, researchers from University of California, Los Angeles have developed a successful treatment to rescue advanced forms of…
Biopharm company, Insmed Incorporated, has announced that they will present their novel inhalation technologies for the treatment of orphan pulmonary diseases such as pulmonary arterial hypertension at the European Respiratory Society’s (ERS) International Congress 2014. Held between September 6th and 10th at the Internationales Congress Center München, in…
Idiopathic pulmonary fibrosis (IPF) is an uncommon, yet deadly respiratory disease, characterized by a progressive decline in pulmonary function caused by lung scarring — the cause of which remains unknown today. Patients diagnosed with IPF along with their significant others recently received the good news that they are finally…
The U.S. District Court for the District of New Jersey has ruled in United Therapeutics Corporation‘s favor in the company’s case against Sandoz, regarding United Therapeutics’ Remodulin product. First approved in the United States in May 2002, Remodulin is a prostacyclin vasodilator used for the treatment of pulmonary arterial…
The U.S. Food and Drug Administration has granted APD811, an investigational drug candidate internally developed by Arena Pharmaceuticals, orphan drug status. APD811 is an oral agonist of the prostacyclin (IP) receptor, which is designed for the treatment of vasospastic diseases, such as pulmonary arterial hypertension (PAH). “The FDA Office of…
Omentin, an adipocyte-derived cytokine, is a potential novel candidate to treat obesity-related cardiovascular disease. Dr. Kyosuke Kazama and colleagues from the School of Veterinary Medicine, Kitasato University, Japan, have shown for the first time that long term treatment for 14 days with omentin inhibits vascular structural remodeling and abnormal contractile…
The first results of AMBITION, a large pulmonary arterial hypertension clinical trial, will be presented this month at the European Respiratory Society (ERS) International Congress 2014, as part of the highlights of the meeting. AMBITION is a randomized, double blind, multi center Phase 4 clinical trial testing the efficacy…
The American College of Chest Physicians’ (CHEST) series of guidelines for the management and treatment of pulmonary arterial hypertension (PAH) in adults, which was published this summer in the CHEST journal, has been officially endorsed by the country’s leading pulmonary hypertension association, the Pulmonary Hypertension Association…
Sorrento Therapeutics, Inc., a late-stage clinical oncology company, has announced that it will advance with its immunotherapy targeting WNT1-Inducible Signaling Protein-1 (WISP1) for the potential treatment of idiopathic pulmonary fibrosis (IPF). IPF is a chronic and fatal disease that occurs in individuals between 50 and 70 years of…
